Benevento have been knocked out of the Coppa Italia in a 4-2 defeat to Empoli, while Brescia pummelled Perugia.
Pippo Inzaghi’s Benevento had been hoping to progress in the tournament, but their journey ends at the Third Round.
Serie B side Empoli came out comfortable winners and all six goals arrived in the second half.
Pasquale Schiattarella saw red for Benevento on 80 minutes, making it even more difficult for the Streghe, who capitulated to a Leonardo Mancosu hat-trick.
Veteran ex-Napoli full-back Christian Maggio had managed a temporary equaliser.
Empoli will face Brescia in the Fourth Round, a side that swept past Perugia 3-0 this evening.
Benevento 2-4 Empoli
Olivieri 47 (E), Maggio 57 (B), Mancuso 60, 66, 85 (E), Moncini 91 (B)
Sent off: Schiattarella 80 (B)
Brescia 3-0 Perugia
Bisoli 10 (B), Aye pen 25 (B), Mangraviti 71 (B)